Achieving high containment during sampling of potent or sensitive products is a major challenge in pharmaceutical and chemical production. The AVM High Containment Powder Sampling Valve is specifically engineered to ensure safe, clean, and fully controlled sampling without exposing operators or the environment to harmful substances.
Our system is designed around strict OEL (Operator Exposure Limit) requirements.
The OEL defines the maximum airborne concentration of an active substance that can be present in the production room without causing any risk to operator health.
AVM’s advanced sampling technology ensures an OEL performance of < 1 μg/m³, making it suitable for handling highly potent APIs and toxic powders.
The standard sampling container has a 250 ml (16 cu in) capacity and connects easily to existing process lines via a DN50 / 2.5" tri-clamp interface. The system integrates seamlessly with the AVM split butterfly valve, providing a reliable, contamination-free transfer between process and sampling points.
High-containment performance ensuring operator and product safety
Quick, tool-free dismantling, including a dedicated cleaning device for efficient turnaround
Compact design for easy installation in restricted production spaces
Zero dead volume construction to prevent product loss and cross-contamination
Smooth integration with AVM split butterfly valve technology for closed, secure sampling
Whether used for routine sampling, batch verification, or quality control, the AVM high-containment sampling device provides a robust and compliant solution for modern high-potency production environmen
In closed position, sealing is formed directly by the piston on the inside wall of the valve, without the need for a gasket.The patented system inside this piston allows the PTFE to expand and ensure a perfect tightness from vacuum up to 10 bar (145 psi).
The advantage of having an expendable piston inside the high containment powder sampling valve is to eliminate the need for O-rings that can be damaged during valve operation.
In this position, the piston will be flush with the connection point, leaving no dead space.
Low retention, no dead corner, high cleanliness, small torque
The airbag and plunger have no friction, so the service life of the valve is extended.
Suitable for: fluids, powders, granules, and other materials.
Valve core material: PTFE + metal scraper/PEEK/PTFE/metal, others available.
Airbag material: Silicon/EPDM/FKM/FFKM; others available
AVM split butterfly valves are designed for high-containment pharmaceutical applications, achieving OEB4–OEB5. The split design ensures easy cleaning and maintenance, reliable sealing, and safe handling of potent compounds.
Sampling bottles can be customized in size and connection type to meet your specific requirements.
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